MC210 (JAN) 2:0 Molecular Oncology

The syllabus of the course is as follows:
Immortalization, transformation, metastasis; Genetic instability: mutation, deletion, insertion, aneuploidy, chromosome translocation and Gene amplification; Cell cycle and cancer: cell cycle checkpoints, G1/S checkpoint, G2/M checkpoint, cyclins and cyclin dependent kinases, CDK inhibitors - p16, p21 and p27; Oncogenes: growth factors, growth factor receptors, G protein/signal transduction, tyrosine and serine/ - threonine kinases and transcription factors; Tumor suppressor genes: p53, RB, BRCA1, BRCA2, APC and WT1; Mismatch repair, Telomerase, DNA methylation, Protein phosphorylation/dephosphorylation and degradation events; Transformation by RNA and DNA tumor viruses: Adenovirus, Simian Virus 40 and Human papilloma virus, Oncogene-tumor suppressor interactions; Apoptosis and cancer, Cancer gene therapy.