We are studying the molecular basis of translational control of Hepatitis C Virus and Coxsackievirus B3 RNAs. Translation of these viral RNAs are guided by Internal Ribosome Entry Site (IRES). Ribosome binding to the IRES element is mediated by a number of cellular proteins (trans acting factors) and cis acting RNA elements. Such RNA-protein interactions that are critical for viral IRES function, form a major research area in the lab. In this context, the group has expanded its scope to investigate the mechanistic details of HCV and CVB3 replication, host-viral interactions and related aspects of immunity. Lately, our group has extended study to non-canonical modes of cellular RNA translation using tumor suppressor p53 RNA as a model system.