P. Ajitkumar, PhD
Associate Professor
Department of Microbiology and Cell Biology
Indian Institute of Science, Bangalore, India
Tel: 080-2293-2344, Fax No. - 91-80-23602697, Email: ajit@mcbl.iisc.ernet.in

   

Mechanisms of bacterial cell division form the theme of research work in my laboratory. The human bacterial pathogens, Mycobacterium tuberculosis, Mycobacterium xenopi, and Mycobacterium leprae, the saprophyte, Mycobacterium smegmatis, and the enteric bacterium,Escherichia coli form the experimental systems to study the phenomenon of bacterial cell division. Specifically, structure and function of the proteins that participate in cell division, regulation of expression of the genes coding for the cell division proteins, and the protein-protein interaction network that regulate cell division are the foci of study in these experimental systems. Also, the modes of regulation of cell division under different stress conditions, such as hypoxia, nutrient depletion, and oxidative stress, are also being investigated. Further, an unusual mode of cell division in mycobacteria, the highly deviated asymmetric cell division, which was discovered in our laboratory, is being studied to understand its mechanism and the physiological significance.