Selected Publications

    • Stephen-Victor E, Karnam A, Fontaine T, Beauvais A, Das M, Hegde P, Prakhar P, Holla S, Balaji KN, Kaveri SV, Latge JP, Aimanianda V, Bayry J: 2017. Aspergillus fumigatus cell wall a-(1,3)-glucan stimulates regulatory T cell polarization by inducing PD-L1 expression on human dendritic cells. J Infect Dis
    • Singh V, Prakhar P, Rajmani RS, Mahadik K, Borbora SM, Balaji KN: 2017. Histone Methyltransferase SET8 Epigenetically Reprograms Host Immune Responses to Assist Mycobacterial Survival. J Infect Dis, 216(4):477-488.
    • Boro M, Balaji KN: 2017. CXCL1 and CXCL2 Regulate NLRP3 Inflammasome Activation via G-Protein-Coupled Receptor CXCR2. J Immunol, 199(5):1660-1671.
    • Maddur MS, Stephen-Victor E, Das M, Prakhar P, Sharma VK, Singh V, Rabin M, Trinath J, Balaji KN, Bolgert F, Vallat JM, Magy L, Kaveri SV, Bayry J: 2017. Regulatory T cell frequency, but not plasma IL-33 levels, represents potential immunological biomarker to predict clinical response to intravenous immunoglobulin therapy. J Neuroinflammation,14(1):58.
    • Boro M, Singh V, Balaji KN: 2016. Mycobacterium tuberculosis-triggered Hippo pathway orchestrates CXCL1/2 expression to modulate host immune responses. Sci Rep, 6:37695.
    • Holla S*, Prakhar P*, Singh V, Karnam A, Mukherjee T, Mahadik K, Parikh P, Singh A, Rajmani RS, Ramachandra SG, Balaji KN: 2016. MUSASHI-Mediated Expression of JMJD3, a H3K27me3 Demethylase, Is Involved in Foamy Macrophage Generation during Mycobacterial Infection. PLoS Pathog, 12(8):e1005814*equal first author
    • Holla S,Stephen-Victor E, Prakhar P, Sharma M, Saha C, Udupa V, Kaveri SV, Bayry J, Balaji KN: 2016. Mycobacteria-responsive sonic hedgehog signaling mediates programmed death-ligand 1 and prostaglandin E2-induced regulatory T cell expansion. Sci Rep, 15;6:24193.
    • Klionsky DJ............ Balaji KN.......... Zughaier SM: 2016. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12(1):1-222
    • Holla S, Balaji KN: 2015. Epigenetics and miRNA during bacteria-induced host immune responses. Epigenomics, 7(7):1197-212.
    • Karnam A*, Holla S*, Balaji KN: 2015. Sonic hedgehog-responsive lipoxygenases and cyclooxygenase-2 modulate Dectin-1-induced inflammatory cytokines. Mol Immunol, Dec;68(2 Pt A):280-9. doi: 10.1016.*equal first author
    • Prakhar P *, Holla S*, Ghorpade DS*, Gilleron M, Puzo G, Udupa V, Balaji KN: 2015. Ac2PIM-responsive miR-150 and miR-143 Target Receptor-interacting Protein Kinase 2 and Transforming Growth Factor Beta-activated Kinase 1 to Suppress NOD2-induced Immunomodulators. J Biol Chem, 290(44):26576-86.*equal first author
    • Singh V*, Holla S*, Ramachandra SG, Balaji KN: 2015. WNT-inflammasome signaling mediates NOD2-induced development of acute arthritis in mice. J Immunol, 194(7):3351-60.*equal first author
    • Prasad KD, Trinath J, Biswas A, Sekar K, Balaji KN*, Guru Row TN*: 2014.Anthrapyrazolone analogues intercept inflammatory JNK signals to moderate endotoxin induced septic shock. Sci Rep, 27;4:7214.*equal corresponding senior author
    • Maddur MS, Trinath J, Rabin M, Bolgert F, Guy M, Vallat JM, Magy L, Balaji KN,Kaveri SV, Bayry J.: 2014.Intravenous immunoglobulin-mediated expansion of regulatory T cells in autoimmune patients is associated with increased prostaglandin E2 levels in the circulation. Cell Mol Immunol,12(5):650-2.
    • Stephen-Victor E, Saha C, Sharma M, Holla S, Balaji KN, Kaveri SV, Bayry J.: 2014.Inhibition of programmed death-1 ligand 1 on dendritic cells enhances Mycobacterium-mediated IFN-gamma production without modulating the frequencies of IFN-gamma-producing CD4+ T cells. J Infect Dis, 15;211(6):1027-9.
    • Trinath J*, Holla S*, Mahadik K, Prakhar P, Singh V, Balaji KN: 2014. WNT signaling pathway contributes to Dectin-1-dependent inhibition of TLR-induced inflammatory signature. Mol Cell Biol, 34(23):4301-14.
      Note: Article selected for "Spotlights" section (page 4215) and "Cover" of Mol Cell Biol for vol. 34, issue 23.*equal first author
    • Holla S*, Ghorpade DS*, Singh V, Bansal K, Balaji KN: 2014. Mycobacterium bovis BCG promotes tumor cell survival from tumor necrosis factor-alpha-induced apoptosis. Mol Cancer, 13(1):210.*equal first author
    • Prasad KD, Trinath J, Biswas A, Sekar K, Balaji KN*, Guru Row TN*: 2014. Alkyl chain substituted 1,9-pyrazoloanthrones exhibit prominent inhibitory effect on c-Jun N-terminal kinase (JNK). Org Biomol Chem, 12(26):4656-4662.*equal corresponding senior author
    • Holla S, Trinath J, Balaji KN: 2014. TNF-alpha modulates TLR2-dependent responses during mycobacterial infection. Methods Mol Biol, 1155:133-150.
    • Kaufmann SHE, Lange C, Rao M, Balaji KN, Lotze M, Schito M, Zumla AI, Maeurer M.: 2014. Progress in tuberculosis vaccine development and host-directed therapies-a state of the art review. Lancet Respir Med, 2(4):301-320.
    • Holla S, Sharma M, Vani J, Kaveri SV, Balaji KN*, Bayry J*: 2014. GM-CSF along with IL-4 but not alone is indispensable for the differentiation of human dendritic cells from monocytes. J Allergy Clin Immunol, 133(5):1500-1502.*equal corresponding senior author
    • Holla S, Kurowska-Stolarska M, Bayry J, Balaji KN: 2014. Selective inhibition of IFNG induced autophagy by Mir155- and Mir31-responsive WNT5A and SHH signaling. Autophagy, 10(2)):311-330.
    • Ghorpade DS*, Sinha AY*, Holla S, Singh V, Balaji KN: 2013. NOD2-nitric oxide-responsive microRNA-146a activates Sonic hedgehog signaling to orchestrate inflammatory responses in murine model of inflammatory bowel disease. J Biol Chem, 288(46):33037-33048. *equal first author
    • Trinath J*, Hegde P*, Sharma M*, Maddur MS, Rabin M, Vallat JM, Magy L, Balaji KN, Kaveri SV, Bayry J: 2013. Intravenous immunoglobulin expands regulatory T cells via induction of cyclooxygenase-2-dependent prostaglandin E2 in human dendritic cells. Blood, 122(8):1419-1427. *equal first author
      RESEARCH HIGHLIGHTS Leah E. (2013) Therapy. New mechanisms of IVIg. Nat Rev Rheumatol , 9(9): 504.
    • Vani J, Shaila MS, Trinath J, Balaji KN, Kaveri SV, Bayry J: 2013. Mycobacterium tuberculosis Cell Wall-Associated Rv3812 Protein Induces Strong Dendritic Cell-Mediated Interferon gamma Responses and Exhibits Vaccine Potential. J Infect Dis, 208(6):1034-1036.
    • Ghorpade DS*, Holla S*, Sinha AY*, Alagesan SK, Balaji KN: 2013. Nitric Oxide and KLF4 Protein Epigenetically Modify Class II Transactivator to Repress Major Histocompatibility Complex II Expression during Mycobacterium bovis Bacillus Calmette-Guerin Infection. J Biol Chem, 288(28):20592-20606. *equal first author
    • Alvarez-Corrales N, Ahmed RK, Rodriguez CA, Balaji KN, Rivera R, Sompallae R, Vudattu NK, Hoffner SE, Zumla A, Pineda-Garcia L, Maeurer M: 2013. Differential cellular recognition pattern to M. tuberculosis targets defined by IFN-gamma and IL-17 production in blood from TB+patients from Honduras as compared to health care workers: TB and immune responses in patients from Honduras. BMC Infect Dis, 13:125.
    • Trinath J, Hegde P, Balaji KN Kaveri SV, Bayry J: 2013. Intravenous immunoglobulin-mediated regulation of Notch ligands on human dendritic cells. J Allergy Clin Immunol, 131(4):1255-1256
    • Ghorpade DS, Holla S, Kaveri SV, Bayry J, Patil SA, Balaji KN: 2013. Sonic hedgehog-dependent induction of microRNA-31 and microRNA-150 regulates M. bovis BCG driven TLR2 signaling. Mol Cell Biol, 33(3):543-556.    EDITORS' CHOICE:- VanHook AM: 2013. Host-Pathogen Interactions: Sonic Hedgehog Mediates Pathogen-Specific Response. Sci Signal , 6: ec20.
    • Verma-Kumar S, Abraham D, Dendukuri N, Cheeran JV, Sukumar R, Balaji KN: 2012. Serodiagnosis of Tuberculosis in Asian Elephants (Elephas maximus) in Southern India: A Latent Class Analysis. PLoS One, 7(11):e49548.
    • Ghorpade DS, Leyland R, Kurowska-Stolarska M, Patil SA, Balaji KN: 2012. MicroRNA-155 is required for M. bovis BCG mediated apoptosis of macrophages. Mol Cell Biol, 32(12):2239-2253.
    • Ahmed RK, Rohava Z, Balaji KN, Hoffner SE, Gaines H, Magalhaes I, Zumla A, Skrahina A, Maeurer MJ: 2012. Pattern recognition and cellular immune responses to novel Mycobacterium tuberculosis -antigens in individuals from Belarus. BMC Infect Dis, 12:41.
    • Trinath J, Maddur MS, Kaveri SV, Balaji KN*, Bayry J*: 2012. Mycobacterium tuberculosis promotes regulatory T cell expansion via induction of programmed death-1 ligand 1 (PD-L1, CD27) on dendritic cells. J Infect Dis, 205(4):694-696. *equal corresponding senior author
    • Kumar SA*, Bansal K*, Holla S*, Verma-Kumar S, Sharma P, Balaji KN: 2012. ESAT-6 induced COX-2 expression involves coordinated interplay between PI3K and MAPK signaling. Mol Immunol, 49(4):655-663. *equal first author
    • Roy S, Narayana Y, Balaji KN, Ajitkumar P: 2012. Highly fluorescent GFPm2+-based genome integration-proficient promoter probe vector to study Mycobacterium tuberculosis promoters in infected macrophages. Microbial Biotechnology, 5(1):98-105.
    • Balaji KN*, Kaveri SV, Bayry J: 2011. Wnt signaling and Dupuytren’s disease. Letter to the Editor, N Engl J Med, 365(18):1740. *corresponding author.
    • Bansal K*, Trinath J*, Chakravortty D, Patil SA, Balaji KN: 2011. Pathogen-specific TLR2 activation programs macrophages to induce Wnt-{beta}-Catenin signaling. J Biol Chem, 286(42):37032-37044. *equal first author
    • Ghorpade DS, Kaveri SV, Bayry J*, Balaji KN*: 2011. Cooperative Regulation of NOTCH1 Protein-Phosphatidylinositol 3-Kinase (PI3K) Signaling by NOD1, NOD2, and TLR2 Receptors Renders Enhanced Refractoriness to Transforming Growth Factor-{beta} (TGF-{beta})- or Cytotoxic T-lymphocyte Antigen 4 (CTLA-4)-mediated Impairment of Human Dendritic Cell Maturation. J Biol Chem, 286(36):31347-31360. *equal corresponding senior author

    • Mukhopadhyay S, Balaji KN: 2011. The PE and PPE proteins of Mycobacterium tuberculosis. Tuberculosis, 91(5):441-447.
    • Bansal K, Balaji KN: 2011. Intracellular pathogen sensor NOD2 programs macrophages to trigger Notch1 activation. J Biol Chem, 18;286(7):5823-35
    • Bansal K, Elluru SR, Narayana Y, Chaturvedi R, Patil SA, Kaveri SV, Bayry J*, Balaji KN*: 2010. PE_PGRS antigens of Mycobacterium tuberculosis induce maturation and activation of human dendritic cells. J Immunol, 184(7):3495-3504. *equal corresponding senior author

    • Bansal K, Sinha AY, Ghorpade DS, Togarsimalemath SK, Patil SA, Kaveri SV, Balaji KN*, Bayry J*: 2010. Src homology 3-interacting domain of Rv1917c of Mycobacterium tuberculosis induces selective maturation of human dendritic cells by regulating PI3K-MAPK-NF-kappaB signaling and drives Th2 immune responses. J Biol Chem, 285(47):36511-36522. *equal corresponding senior author

    • Chaturvedi R*, Bansal K*, Narayana Y, Kapoor N, Sukumar N, Togarsimalemath SK, Chandra N, Mishra S, Ajitkumar P, Joshi B,Katoch V M, Patil SA, Balaji KN: 2010. The multifunctional PE_PGRS11 protein from Mycobacterium tuberculosis plays a role in regulating resistance to oxidative stress. J Biol Chem, 285(40):30389-30403. *equal first author
    • Das P, Lahiri A, Sen M, Iyer N, Kapoor N, Balaji KN, Chakravortty D: 2010. Cationic amino acid transporters and Salmonella Typhimurium ArgT collectively regulate arginine availability towards intracellular Salmonella growth. PLoS One, 5(12):e15466.
    • Kapoor N, Narayana Y, Patil SA, Balaji KN: 2010. Nitric oxide is involved in Mycobacterium bovis bacillus Calmette-Guerin-activated Jagged1 and Notch1 signaling. J Immunol, 184(6):3117-3126.
    • Maddur MS, Vani J, Dimitrov JD, Balaji KN, Lacroix-Desmazes S, Kaveri SV, Bayry J: 2010. Dendritic Cells in Autoimmune Diseases. The Open Arthritis Journal, 3:1-7.
    • Bansal K*, Kapoor N*, Narayana Y, Puzo G, Gilleron M, Balaji KN: 2009. PIM2 Induced COX-2 and MMP-9 expression in macrophages requires PI3K and Notch1 signaling. PLoS One, 4(3):e4911.  *equal first author
    • Bansal K, Narayana Y, Balaji KN: 2009 Inhibition of TNF-alpha-induced cyclooxygenase-2 expression by Mycobacterium bovis BCG in human alveolar epithelial A549 cells. Scand J Immunol, 69(1):11-19.
    • Bansal K, Narayana Y, Patil SA, Balaji KN: 2009. M. bovis BCG induced expression of COX-2 involves nitric oxide-dependent and -independent signaling pathways. J Leukoc Biol, 85(5):804-816
    • Narayana Y, Bansal K, Sinha AY, Kapoor N, Puzo G, Gilleron M, Balaji KN: 2009. SOCS3 expression induced by PIM2 requires PKC and PI3K signaling. Mol Immunol, 46(15):2947-2954.
    • Mishra KC, de Chastellier C, Narayana Y, Bifani P, Brown AK, Besra GS, Katoch VM, Joshi B, Balaji KN, Kremer L: 2008. Functional role of the PE domain and immunogenicity of the Mycobacterium tuberculosis triacylglycerol hydrolase LipY. Infect Immun, 76(1):127-140.
    • Narayana Y, Balaji KN: 2008. NOTCH1 up-regulation and signaling involved in Mycobacterium bovis BCG-induced SOCS3 expression in macrophages. J Biol Chem, 283(18):12501-12511.
    • Srinivas M, Rajakumari S, Narayana Y, Joshi B, Katoch VM, Rajasekharan R, Balaji KN: 2008. Functional characterization of the phospholipase C activity of Rv3487c and its localization on the cell wall of Mycobacterium tuberculosis. J Biosci, 33(2):221-230.
    • Balaji KN*, Goyal G, Narayana Y, Srinivas M, Chaturvedi R, Mohammad S: 2007. Apoptosis triggered by Rv1818c, a PE family gene from Mycobacterium tuberculosis is regulated by mitochondrial intermediates in T cells. Microbes Infect, 9(3):271-281. *corresponding author
    • Narayana Y, Joshi B, Katoch VM, Mishra KC, Balaji KN: 2007. Differential B-cell responses are induced by Mycobacterium tuberculosis PE antigens Rv1169c, Rv0978c, and Rv1818c. Clin Vaccine Immunol, 14(10):1334-1341.
       
     
         
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