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Research

Research overview-

Mycobacteria, including Mycobacterium tuberculosis and Mycobacterium bovis are extremely successful pathogens with the former afflicting more than one-third of the human population. Upon infection with M. tuberculosis, only about 10% of the infected populace goes on to develop active tuberculosis (TB) disease. The rest exhibit a clinically latent infection characterized by the persistence of, possibly, dormant bacilli. Approximately 10% of latently infected individuals progress to a highly contagious disease state, called reactivation TB. The reactivation risk is higher when confounded by immune-suppression, for example, upon co-infection with HIV/AIDS. The host-pathogen interplay is complex. Our research interest lies in studying the immunological parameters associated with host- Mycobacterium tuberculosis interactions during pulmonary-, latent- and reactivation TB. We are also investigating the signaling pathways and immunological responses orchestrated by various pathogen recognition receptors (PRRs) like Toll-like receptors (TLRs), NOD-like receptors (NLRs) and C-type lectin receptors (CLRs) viz Dectin-1. Mycobacteria-responsive epigenetic regulation of immune responses is another area of our interest.

Group Member 

Gaurav Kumar Lohia

Gaurav Kumar Lohia

Int. PhD Student

Year of Joining IISc: 2015
Masters: B.Sc. (Microbiology hons.),
Ram Lal Anand college, University of Delhi, Delhi
email ID: gauravlohia@iisc.ac.in

Ashish Bijewar

Ashish Bijewar

PhD Student

Year of Joining IISc: 2017
Masters: M.Sc. (Biotechnology),
Dr. Baba Saheb Ambedkar Marathwada University, Aurangabad, Maharashtra
email ID: ashishb@iisc.ac.in

Mahima

Mahima

PhD Student

Year of Joining IISc: 2018
Masters: M.Sc. (Life Sciences),
School of Life Sciences, Jawaharlal Nehru University, Delhi
email ID: mahima16331@iisc.ac.in

Ankita Ghoshal

Ankita Ghoshal

PhD Student

Year of Joining IISc: 2018
Masters: M.Sc. (Microbiology), Banaras Hindu University, UP
email ID: ankitag@iisc.ac.in

Awantika Shah

Awantika Shah

Int. PhD Student

Year of joining IISc: 2018
Bachelors: B.Sc. (Biotechnology),
Fergusson College, Pune University, Maharashtra
email ID: awantikashah@iisc.ac.in

Aditi Singh

Aditi Singh

PhD Student

Year of Joining IISc: 2020
Bachelors: B.tech (Bio-Technology), Dr. A.P.J. Abdul Kalam Technical University, Uttar Pradesh
email ID: aditisingh@iisc.ac.in

Smriti Sundar

Smriti Sundar

PhD Student

Year of Joining IISc: 2021
Masters: M.Sc (Biotechnology), IIT Roorkee, Uttarakhand
email ID: smritisundar@iisc.ac.in

Babita Kumari

Babita Kumari

Int. PhD Student

Year of joining IISc: 2020
Bachelors: B.Sc. Hons.(Microbiology),
Shaheed Rajguru College of Applied Sciences for Women
email ID: babitakumari@iisc.ac.in

Shashaank G

Shashaank G

PhD Student

Year of Joining IISc: 2022
Masters: BS-MS (Biological Sciences), IISER Bhopal, Madhya Pradesh
email ID: shashchennai87@gmail.com

Nidhi Srinivasan

Nidhi Srinivasan

Project assistant

Year of Joining IISc: 2022
Masters: M.Sc (Genetics), University of Mysore, Karnataka
email ID: nidhis@iisc.ac.in

K. Benasir

K. Benasir

Lab Manager

Year of joining IISc: 2017
Bachelor’s: B.Sc (Computer Science)
email ID: benasirk@iisc.ac.in

Alumni

  1. Dr. Yeddula Narayana
  2. Dr. Kanhu C. Mishra
  3. Dr. Rashmi Chaturvedi
  4. Dr. Kushagra Bansal
  5. Dr. Nisha Kapoor
  6. Dr. Akhauri Yash Sinha
  7. Dr. DevramSampatGhorpade
  8. Dr. JammaTrinath
  9. Dr. Sahana Holla
  10. Dr. M. Ravinder Naick
  11. Dr. Vikas Singh
  12. Dr. MonoranjanBoro
  13. Dr. Praveen Prakhar
  14. Dr. Kasturi Mahadik
  15. Dr. Tanushree Mukherjee
  16. Dr. Bharat Bhatt
  17. Dr. Preeti Yadav
  18. Tanisha Malpani (UG student)
  19. Dr. Salik Miskat Borbora

 

 

Project assistants

  • Anupama Karnam
  • Vibha A.V. Uduppa
  • Sneha Bhatt
  • Sravani Mareddy

 

 

Publications

Research Articles and Scientific Reviews

(click here)

 

Number of books authored/edited: 1 book chapter

  • Holla, S., Trinath, J., and Balaji, K. N. TNF-alpha modulates TLR2-dependent responses during mycobacterial infection, Methods Mol Biol. 2014, 1155, 133-150.

 

 

 

 

K. N. Balaji

K. N. Balaji

PROFESSOR

Email: balaji@iisc.ac.in

PUBLICATIONS (Click here)