Menu

Research

Sirtuins in Cardiovascular diseases 

Our lab studies Sirtuins, a family of histone deacetylases. Mammalian genome encodes seven Sirtuin isoforms (SIRT1-SIRT7), which differ in their structures, substrate specificities and subcellular localizations.We study how they regulate the pathophysiology of heart failure induced by hypertension, myocardial infarction and metabolic diseases. We use primary cell cultures, transgenic, dietary and surgical mouse models to test Sirtuins for their ability to protect against cardiovascular disease. Our lab techniques range from physiology and biochemistry, to molecular biology and proteomics. Ongoing work in our lab involves studies of the role of Sirtuins in cardiac hypertrophy, fibrosis, mitochondrial dysfunction and muscle degeneration. Our goal is to disclose new biological functions of Sirtuins that can be therapeutically targeted for promoting health-span of heart.

Group Member 

Shweta Kumar

Shweta Kumar

PhD students

Year of joining: 2015 (Ph.D.)
M.Sc. Genetics – University of Delhi
E-mail: shwetakumar[at]iisc.ac.in

Ankit Kumar Tamta

Ankit Kumar Tamta

PhD students

Year of joining: 2014 (Int. Ph.D.)
B.Tech. Biotechnology – G.B. Pant University of Agriculture and Technology
E-mail: ankittamta[at]iisc.ac.in

Sukanya R

Sukanya R

PhD students

Year of joining: 2015 (Ph.D.)
B.E. Biotechnology – R V College of Engineering, Bangalore
E-mail: sukanyaraghu@iisc.ac.in

Aditi Jain

Aditi Jain

PhD students

Year of joining: 2015 (Interdisplinary Ph.D. (BioSystems Science and Engineering))
Joint advisor: Dr. Kaushik Chatterjee M.Sc. Biotechnology- IIT Bombay
E-mail: aditijain@iisc.ac.in

Danish Khan

Danish Khan

PhD students

Year of Joining- 2014 (Integrated PhD) Department MCB joining -2015
B.Sc : Patna Science college
E-mail: danishttanvir786@gmail.com

Arushi Taneja

Arushi Taneja

PhD students

Year of joining: 2018 (Int. Ph.D.)
B.Sc. (Hons) Biochemistry – University of Delhi
E-mail: arushitaneja@iisc.ac.in

Sima Zarinfard

Sima Zarinfard

PhD students

Year of joining: 2019 ( Ph.D.)
M.Sc. Biotechnology – Amity University, Rajasthan
E-mail: simaz@iisc.ac.in

Thoniparambil Sunil Sumi

Thoniparambil Sunil Sumi

PhD Students

Year of joining: 2019 ( Ph.D.)
MSc. Microbiology – Mahatma Gandhi University, Kottayam.
E-mail: tsumi@iisc.ac.in

Satya Chaithanya Duggisetty

Satya Chaithanya Duggisetty

PhD Students

Year of joining: 2019 (PhD)
Co-guide- Anand Srivastava (MBU) MTech – IIITDM kancheepuram
E-mail : satyad@iisc.ac.in

Dr. Arathi B P

Dr. Arathi B P

Post doc

Year of joining: 2018 (D.S. Kothari Postdoctoral Fellow)
Ph.D.- Bangalore University
E-mail: arathib@iisc.ac.in

Dr. Sunayana N

Dr. Sunayana N

Post doc

Year of joining: 2018 (ICMR RA)
Ph.D.- University of Mysore
E-mail: nsunayana@iisc.ac.in
Dr. R Dhevi

Dr. R Dhevi

Post doc

Year of joining: 2019 (RA)
Ph.D. in Biochemistry – Tamil University, Thanjavur)
E-mail: dhevir@iisc.ac.in

Dr. Parthasarathy R

Dr. Parthasarathy R

Research Associates

Year of joining: 2020 (RA)
Ph.D., Bharathidasan University
E-mail: parthasarthy@iisc.ac.in

Shalini Srinivasan

Shalini Srinivasan

Project Assistants

Year of joining: 2019 (Project Assistant)
M.Sc. Biochemistry- Bangalore University
E-mail : shalluisnow@gmail.com

M. Bhavya Madhuri

M. Bhavya Madhuri

Project Assistants

Year of joining: 2019 (Project assistant)
M.Sc. Biochemistry – Andhra University
Email: mbhavyamadhuri@gmail.com

Lavanya Dindi

Lavanya Dindi

Project Assistants

Year of joining: 2019 (project assistant)
M.Sc- Biochemistry- Andhra University, Visakhapatnam.
Email: dindilavanya95@gmail.com

Srishti Shekhar

Srishti Shekhar

Project Assistants

Year of joining: 2019 ( Project Assistant)
M.Sc Medical Biotechnology -Maharaja Sayajirao University (MSU, Baroda)
Email id : srishti.shekhar05@gmail.com

Archana R

Archana R

Project Assistants

Year of Joining: 2019 (Project assistant)
M.Sc Applied Microbiology – University of Madras
E-mail: rarchana@iisc.ac.in

Tarannum Ara

Tarannum Ara

Project Assistants

Year of joining: 2014 (JRF)
M.Sc Biotechnology Jawaharlal Nehru University
E-mail: tarannumara835@gmail.com
Title:Working on role of Sirtuins on Cardiac metabolism

Awards & Patents

Text Here

News

News Here 

Alumni

N. Ravi Sundaresan

N. Ravi Sundaresan

Associate Professor

E.mail: rsundaresan@iisc.ac.in

Publications